MOC - Diseases by System

Infectious diseases mapped by organ system — pathogens, specimens, and links into organism + lab notes.

Parent: Home · Map: Encyclopedia Map · Sister hub: MOC - Clinical Microbiology

Overview

Use this MOC when thinking anatomy-first (Where is the infection?).
Use MOC - Clinical Microbiology when thinking workflow-first (Which specimen / method?).

Both hubs should stay cross-linked; disease notes live under 09-Microbiology/Diseases by System/.

flowchart TB
  MOC[MOC - Diseases by System]
  MOC --> CNS[[CNS Infections]]
  MOC --> RESP[[Respiratory Infections]]
  MOC --> CV[[Cardiovascular Infections]]
  MOC --> GI[[Gastrointestinal Infections]]
  MOC --> GU[[Genitourinary Infections]]
  MOC --> SSTI[[Skin and Soft Tissue Infections]]
  MOC --> BJ[[Bone and Joint Infections]]
  MOC --> BSI[[Bloodstream and Sepsis]]
  MOC --> HEENT[[HEENT Infections]]
  MOC --> DEV[[Device-Associated Infections]]

Systems Index

System hub	Disease notes (starter)	Starter pathogens
CNS Infections	Bacterial Meningitis · HSV Encephalitis	Streptococcus pneumoniae · Neisseria meningitidis · HSV
Respiratory Infections	Community-Acquired Pneumonia · Hospital-Acquired Pneumonia · Tuberculosis	Streptococcus pneumoniae · Mycobacterium tuberculosis
Cardiovascular Infections	Infective Endocarditis	Staphylococcus aureus
Gastrointestinal Infections	Clostridioides difficile Infection	Escherichia coli · C. difficile
Genitourinary Infections	Acute Cystitis · Acute Pyelonephritis · Gonorrhea	Escherichia coli · Neisseria gonorrhoeae
Skin and Soft Tissue Infections	Cellulitis and Skin Abscess · Necrotizing Soft Tissue Infection	Staphylococcus aureus · Streptococcus pyogenes
Bone and Joint Infections	Acute Osteomyelitis · Septic Arthritis · Prosthetic Joint Infection	Staphylococcus aureus
Bloodstream and Sepsis	Sepsis · CLABSI · Malaria	Staphylococcus aureus · Plasmodium
HEENT Infections	Streptococcal Pharyngitis	Streptococcus pyogenes · Streptococcus pneumoniae
Device-Associated Infections	CLABSI · (VAP → Hospital-Acquired Pneumonia)	Staphylococcus aureus · Pseudomonas aeruginosa · Biofilm

All disease notes

Phase 1 (14):

• Bacterial Meningitis
• Community-Acquired Pneumonia · Hospital-Acquired Pneumonia
• Infective Endocarditis
• Clostridioides difficile Infection
• Acute Cystitis · Acute Pyelonephritis
• Cellulitis and Skin Abscess · Necrotizing Soft Tissue Infection
• Acute Osteomyelitis · Septic Arthritis
• Sepsis · CLABSI
• Streptococcal Pharyngitis

Phase 2 (2026-08-02):

• Tuberculosis · HSV Encephalitis · Gonorrhea · Prosthetic Joint Infection · Malaria

Template for new diseases: Template - Disease

Core Concepts

• Infectious Disease · Pathogen · Normal Microbiota
• Biofilm · Capsule
• Germ Theory · Koch’s Postulates

Diagnostic and Lab Methods

• MOC - Diagnostic & Lab Methods
• Figure - Diagnostic Workflow
• Gram Stain · Culture and Isolation · PCR · Antimicrobial Susceptibility Testing

Domain MOCs (etiology lenses)

• MOC - Bacteriology · MOC - Virology · MOC - Mycology · MOC - Parasitology
• MOC - Antimicrobials · MOC - Antimicrobial Resistance (AMR)
• MOC - Immunology

Learning Aids

• Media hub: Learning Media Hub
• Workflow figure: Figure - Diagnostic Workflow

Example

Case: Fever + nuchal rigidity.
System first: CNS Infections → CSF Gram Stain + culture/PCR → likely Streptococcus pneumoniae or Neisseria meningitidis.
Workflow twin: same case under MOC - Clinical Microbiology.

Research Questions

1. Which syndromes still need culture for AST vs NAAT-first pathways?
2. How should system pages handle polymicrobial / microbiome-associated disease?

Build Status

Cluster	Status
This MOC + 10 system hubs	done
Starter individual disease notes (14)	done
Next diseases: TB, influenza, HSV encephalitis, gonorrhea, PJI, malaria…	backlog
Viral / fungal / parasitic depth per system	expand next

Related MOCs

• MOC - Clinical Microbiology
• MOC - Fundamentals of Microbiology
• MOC - Bacteriology
• MOC - Diagnostic & Lab Methods