MOC - Immunology
Host defense at the host–pathogen interface — innate/adaptive immunity, vaccines, and immunopathogenesis.
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Overview
Immunology explains why the same Pathogen causes colonization in one host and lethal disease in another — and how vaccines and immune evasion shape outcomes.
Core Concept Notes
- Innate Immunity — barriers, phagocytes, PRRs, inflammation
- Adaptive Immunity — B/T cells, memory, primary vs secondary response
- Antibodies and Immunoglobulin Classes — IgM/IgG/IgA/IgE; serology logic
- Complement System — opsonization, lysis; Neisseria susceptibility
- Vaccination — platforms, conjugates, herd immunity (Public Health hub)
Key Subtopics
- Hypersensitivity & immunopathology (e.g., post-strep sequelae)
- Immunodeficiency → opportunistic infection patterns (CMV, TB, NTM)
- Vaccine-preventable disease links across MOCs
Links to Microbiology
- Capsule (antiphagocytic) · vaccine antigens (Streptococcus pneumoniae, Hib, meningococcus)
- Normal Microbiota and immune education
- Phage toxins / superantigens (Streptococcus pyogenes, S. aureus)
- Serology: Serology in Clinical Microbiology
- History: Edward Jenner · Louis Pasteur
Related MOCs
- MOC - Fundamentals of Microbiology · MOC - Clinical Microbiology
- MOC - Virology · MOC - Bacteriology · MOC - Parasitology
- Computational: AI for Vaccine Design · Microbial Transcriptomics · MOC - AI in Microbiology
Build Status
| Cluster | Status |
|---|---|
| Hub scaffold | done |
| Core immunity concept notes | ✅ 2026-08-02 |
| Hypersensitivity / autoimmunity deep notes | optional backlog |