Community-Acquired Pneumonia

System: Respiratory Infections · Parent MOC: MOC - Diseases by System

One-Sentence Definition

Acute infection of the pulmonary parenchyma acquired outside the hospital, ranging from mild outpatient disease to life-threatening sepsis.

Clinical Presentation

  • Cough, fever, dyspnea, pleuritic pain; focal crackles / consolidation
  • Elderly: may present with falls, delirium, fewer respiratory complaints
  • Severity tools (e.g., CURB-65 / clinical judgment) guide site of care

Pathogens

ContextOrganismNotes
Classic lobarStreptococcus pneumoniaeStill top bacterial CAP
Alcoholism / aspiration associationsKlebsiella pneumoniaeCurrant-jelly lore; mucoid Capsule
Post-viral / severeStaphylococcus aureusIncl. MRSA in selected risks
AtypicalsMycoplasma, Legionella, Chlamydia (TBD)Often PCR/urine Ag for Legionella
ViralInfluenza, SARS-CoV-2, RSV (TBD)MOC - Virology

Pathogenesis

  • Inhalation/aspiration of organisms past airway defenses → alveolar inflammation
  • Bacteremic pneumococcal disease → link Bloodstream and Sepsis

Diagnosis

StepTestNote
ImagingCXR / CTInfiltrate supports diagnosis
Micro (inpatient / severe)Blood culture, sputum Gram Stain/cultureQuality sputum matters
AdjunctUrine pneumococcal / Legionella AgSyndrome-dependent
MolecularRespiratory PCR panelColonization ≠ etiology for some bacteria

Treatment Principles

  • Empiric: cover pneumococcus ± atypicals per guideline/local resistance
  • Escalate for MRSA/Pseudomonas only with risk factors (those → think HAP spectrum)
  • Definitive: narrow with culture/AST; short courses when stable
  • Supportive O₂, fluids; steroids in select severe cases per evidence/guidelines

Prevention

  • Pneumococcal + influenza (+ COVID) vaccination
  • Smoking cessation

Differential / Pitfalls

  • PE, CHF, aspiration pneumonitis without infection, TB, cancer
  • Treating nasal PCR positives as pneumonia without infiltrate/clinical fit

Learning Aids

Diagrams

Clinical Example

Example

Case: 45M, acute fever, rusty sputum, lobar consolidation; sputum Gram: GPC pairs.
Question: Likely pathogen and key prevention message after recovery?
Answer: Streptococcus pneumoniae. Ensure pneumococcal/influenza vaccine status addressed.

Learning Media Hub

Active Recall

  1. Most common typical bacterial cause of CAP?
  2. When to get blood cultures in CAP?
  3. How does colonization confound respiratory PCR?