Bloodstream and Sepsis
Parent: MOC - Diseases by System · Workflow: MOC - Clinical Microbiology
Disease Notes
- Sepsis ✅
- CLABSI ✅
- Infective Endocarditis (source/complication)
Syndromes
| Syndrome | Disease note | First specimens / methods |
|---|---|---|
| Bacteremia | See organism + source disease | Repeat sets; Gram Stain; ID + AST |
| Sepsis / septic shock | Sepsis | Cultures before abx; source hunt |
| Line-associated BSI | CLABSI | Paired cultures; device removal rules |
| Candidemia | TBD | Blood culture; ophthalmology often |
| Contaminant vs true | — | Judgment + Normal Microbiota |
Pathogens (starter)
- Staphylococcus aureus — always significant until proven otherwise
- Escherichia coli · Klebsiella pneumoniae · Pseudomonas aeruginosa
- Streptococci, Enterococcus, Candida (expand)
Key Concepts
- Every bacteremia has a source system — cross-link CNS / lung / urine / SSTI / device / endocarditis
- LPS / toxin physiology → Bacterial Cell Wall · organism toxin notes
- Figure - Diagnostic Workflow